QuickView for Pp2B 14D;jsessionid=2B74423D88A91C4FD35FBC0499F87FBA (gene)
- Gene Symbol:
- PPP3CA
Homo sapiens - Full name:
- protein phosphatase 3 catalytic subunit alpha
- Synonyms:
- CALN, CALNA, CALNA1, CCN1, CNA1, IECEE, PPP2B, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, CAM-PRP catalytic subunit, calcineurin A alpha, calmodulin-dependent calcineurin A subunit alpha isoform, protein phosphatase 2B, catalytic subunit, alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform, protein phosphatase 3 catalytic subunit alpha isozyme
- Genomic Location:
- Chr 4: 102163610-102487376
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Canis lupus familiaris , Pan troglodytes , Danio rerio , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for let-7 , Predicted Gene Targets for miR-103 , Predicted Gene Targets for miR-142-3p , Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-145 , Predicted Gene Targets for miR-153 , Predicted Gene Targets for miR-186 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-21 , Predicted Gene Targets for miR-30
- Cytogenetic Map:
-
4q24
GO Molecular Function
protein serine/threonine phosphatase activity | peptide binding | cation binding | cyclosporin A binding | enzyme binding | phosphatase activity | hydrolase activity | catalytic activity | phosphoprotein phosphatase activity | amide binding | hydrolase activity, acting on ester bonds | protein heterodimerization activity | ion binding | protein binding | protein dimerization activity | phosphoric ester hydrolase activity | calcium ion binding | drug binding | calmodulin-dependent protein phosphatase activity | calmodulin binding | metal ion binding | calcium-dependent protein serine/threonine phosphatase activity
GO Biological Process
protein serine/threonine phosphatase activity | brain development | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | protein dephosphorylation | cellular response to glucose stimulus | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | immune response-regulating signaling pathway | muscle tissue development | negative regulation of peptide secretion | intracellular signal transduction | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | response to metal ion | cell differentiation | excitatory postsynaptic potential | negative regulation of dendrite development | striated muscle cell development | nervous system development | response to drug | cellular chemical homeostasis | inositol phosphate-mediated signaling | neurogenesis | glucose homeostasis | negative regulation of gene silencing by RNA | negative regulation of protein secretion | positive regulation of cellular component movement | regulation of peptide hormone secretion | generation of neurons | intracellular transport | positive regulation of cellular biosynthetic process | cellular process | regulation of production of miRNAs involved in gene silencing by miRNA | regulation of cell motility | localization | cellular homeostasis | regulation of calcium-mediated signaling | protein transport | negative regulation of signaling | metal ion transport | myotube cell development | chemical synaptic transmission | regulation of skeletal muscle adaptation | macromolecule localization | negative regulation of secretion | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | negative regulation of hormone secretion | response to inorganic substance | establishment of localization in cell | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | muscle structure development | muscle cell differentiation | skeletal muscle organ development | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | protein import into nucleus | regulation of gene silencing by miRNA | negative regulation of cell morphogenesis involved in differentiation | T cell activation | phosphatase activity | head development | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | muscle cell development | regulation of insulin secretion | response to stress | intracellular protein transport | skeletal muscle tissue development | negative regulation of neuron projection development | protein localization to nucleus | response to glucose | cellular localization | divalent metal ion transport | regulation of gene silencing | cell cycle G1/S phase transition | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | modulation of chemical synaptic transmission | macromolecule modification | cell-cell signaling | regulation of chromatin binding | muscle fiber development | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | regulation of membrane potential | response to nitrogen compound | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of secretion by cell | Wnt signaling pathway | multicellular organism development | cellular glucose homeostasis | phosphorus metabolic process | regulation of hormone levels | regulation of hormone secretion | regulation of neuron differentiation | regulation of gene expression | regulation of postsynaptic membrane potential | negative regulation of gene silencing by miRNA | organic substance transport | nervous system process | cell cycle | synaptic signaling | positive regulation of cellular metabolic process | negative regulation of chromatin binding | phosphoprotein phosphatase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | peptide transport | positive regulation of intracellular signal transduction | regulation of cellular component movement | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of binding | import into nucleus | Fc-epsilon receptor signaling pathway | second-messenger-mediated signaling | positive regulation of calcium-mediated signaling | non-canonical Wnt signaling pathway | positive regulation of cell migration | negative regulation of dendrite morphogenesis | cardiac muscle hypertrophy | negative regulation of peptide hormone secretion | response to toxic substance | response to xenobiotic stimulus | mitotic cell cycle phase transition | phosphate-containing compound metabolic process | protein import | cellular response to drug | regulation of cardiac muscle hypertrophy in response to stress | striated muscle tissue development | cell communication | regulation of cellular metabolic process | positive regulation of signal transduction | homeostatic process | G1/S transition of mitotic cell cycle | response to monosaccharide | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | striated muscle cell differentiation | lymphocyte activation | positive regulation of molecular function | calcium-mediated signaling | negative regulation of gene silencing | transition between fast and slow fiber | Wnt signaling pathway, calcium modulating pathway | multicellular organismal response to stress | regulation of cell morphogenesis involved in differentiation | protein metabolic process | regulation of cardiac muscle hypertrophy | regulation of establishment of protein localization | response to organic substance | negative regulation of cell projection organization | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | establishment of protein localization to organelle | anatomical structure development | response to amine | regulation of dendrite morphogenesis | mitotic cell cycle | cell surface receptor signaling pathway | positive regulation of connective tissue replacement | metabolic process | positive regulation of cardiac muscle hypertrophy in response to stress | regulation of RNA biosynthetic process | cellular protein localization | cellular response to carbohydrate stimulus | regulation of tissue remodeling | amide transport | regulation of vesicle-mediated transport | chemical homeostasis | calcium ion transport | regulation of secretion | regulation of gene silencing by RNA | organic substance metabolic process | nuclear transport | negative regulation of gene expression | animal organ development | negative regulation of neuron differentiation | regulation of protein secretion | regulation of calcineurin-NFAT signaling cascade | calcineurin-mediated signaling | calcineurin-NFAT signaling cascade | establishment of protein localization | positive regulation of calcineurin-NFAT signaling cascade | cell activation | regulation of dendrite development | regulation of cell communication | dephosphorylation | negative regulation of molecular function | negative regulation of insulin secretion | signaling | regulation of transcription, DNA-templated | myotube differentiation | cell development | regulation of endocytosis | protein localization | regulation of production of small RNA involved in gene silencing by RNA | cellular protein metabolic process | cation transport | cellular macromolecule localization | nucleocytoplasmic transport | positive regulation of tissue remodeling | regulation of nervous system development | regulation of developmental process | developmental process | Fc receptor signaling pathway | calmodulin-dependent protein phosphatase activity | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | cell cycle phase transition | positive regulation of transcription by RNA polymerase II | response to calcium ion | central nervous system development | positive regulation of metabolic process | response to amphetamine | ion transport | regulation of cell projection organization | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | calcium-dependent protein serine/threonine phosphatase activity | positive regulation of cell motility | response to carbohydrate | negative regulation of cell development | carbohydrate homeostasis | muscle hypertrophy | positive regulation of endocytosis | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | muscle system process | cardiac muscle hypertrophy in response to stress | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | negative regulation of production of miRNAs involved in gene silencing by miRNA | skeletal muscle fiber development | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process
GO Cellular Component
supramolecular fiber | dendritic spine | cytoplasmic side of plasma membrane | dendrite | intracellular membrane-bounded organelle | sarcolemma | synapse | catalytic complex | neuron projection | somatodendritic compartment | sarcomere | cell | cytoplasmic side of membrane | nuclear lumen | myofibril | cytoplasm | intracellular organelle | dendritic tree | contractile fiber | cell-cell junction | protein-containing complex | cell projection | neuron spine | postsynapse | nucleoplasm | plasma membrane | mitochondrion | protein serine/threonine phosphatase complex | membrane-bounded organelle | nucleus | organelle | I band | calcineurin complex | cell periphery | membrane-enclosed lumen | Z disc | cytosol | slit diaphragm | intracellular | cell junction | membrane | supramolecular complex
